ABSTRACT
PURPOSE: Despite the increasing incidence of pediatric Crohn disease (CD) in Korea, data on the characteristics of perianal lesions are scarce. Therefore, we aimed to investigate the characteristics of pediatric CD with accompanying perianal lesions in Korea. METHODS: We retrospectively reviewed the medical records of children (age ≤18 years) with confirmed CD at Gachon University Gil Medical Center between 2000 and 2014. Patients were classified into two groups based on the presence or absence of any perianal lesions including skin tags. Additional analysis was performed according to the presence or absence of perianal perforating lesions. RESULTS: Among the 69 CD children (mean age, 15.4 years) include in the analysis, 54 (78.3%) had a perianal lesion and 29 (42.0%) had a perianal perforating lesion. The median duration of chief complaints was longer in pediatric CD with any accompanying perianal lesions (5.40 months vs. 1.89 months, p=0.02), while there was no difference between pediatric CD with and without perianal perforating lesions (5.48 months vs. 4.02 months, p=0.18). Perianal symptoms preceded gastrointestinal symptoms in 13 of 29 (44.8%) patients with perianal perforating lesions. CONCLUSIONS: CD should be suspected in children with perianal lesions, even in circumstances when gastrointestinal symptoms are absent.
Subject(s)
Child , Humans , Crohn Disease , Incidence , Korea , Medical Records , Retrospective Studies , SkinABSTRACT
Malignant glomus tumor is an exceedingly rare neoplasm occurring in the soft tissues. Controversy exists over whether malignant glomus tumor is a true malignancy due to the rarity of metastasis, however, this neoplasm has been known to show relatively frequent metastasis and poor outcome. To improve the outcome of systemic therapy for malignant glomus tumor might be necessary, but the appropriate chemotherapy or radiotherapy has yet to be elucidated. We report a case of malignant glomus tumor with multiple pulmonary metastases treated with total surgical resection and adjuvant chemotherapy including doxorubicin and ifosfamide; however 7 months after completion of chemotherapy primary lung nodules increased. This case suggests that these chemotherapeutic agents are not effective for the management of malignant glomus tumor with metastasis.
Subject(s)
Female , Humans , Chemotherapy, Adjuvant , Doxorubicin , Drug Therapy , Glomus Tumor , Ifosfamide , Lung , Neoplasm Metastasis , Radiotherapy , ShoulderABSTRACT
Malignant glomus tumor is an exceedingly rare neoplasm occurring in the soft tissues. Controversy exists over whether malignant glomus tumor is a true malignancy due to the rarity of metastasis, however, this neoplasm has been known to show relatively frequent metastasis and poor outcome. To improve the outcome of systemic therapy for malignant glomus tumor might be necessary, but the appropriate chemotherapy or radiotherapy has yet to be elucidated. We report a case of malignant glomus tumor with multiple pulmonary metastases treated with total surgical resection and adjuvant chemotherapy including doxorubicin and ifosfamide; however 7 months after completion of chemotherapy primary lung nodules increased. This case suggests that these chemotherapeutic agents are not effective for the management of malignant glomus tumor with metastasis.